Rejection from those we love--we've all faced it.
This is one of few things that can actually trigger me. (Ooh, triggering; Tumblr would be proud.)
No, but seriously though. If I put my trust in someone and they reject/ betray me in any way, shape, or form: it speaks volumes about that person. Especially given the fact that I hardly trust anyone. So, in conclusion, don't put your trust in anyone.